一种细胞周期调控的细胞周期蛋白依赖性激酶抑制剂。
A cell cycle-regulated inhibitor of cyclin-dependent kinases.
作者信息
Hengst L, Dulic V, Slingerland J M, Lees E, Reed S I
机构信息
Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037.
出版信息
Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5291-5. doi: 10.1073/pnas.91.12.5291.
Cyclin-dependent kinases (Cdks) previously have been shown to drive the major cell cycle transitions in eukaryotic organisms ranging from yeast to humans. We report here the identification of a 28-kDa protein, p28Ick (inhibitor of cyclin-dependent kinase), that binds to and inhibits the kinase activity of preformed Cdk/cyclin complexes from human cells. p28 inhibitory activity fluctuates during the cell cycle with maximal levels in G1 and accumulates in G1- and G0-arrested cells. These results suggest that control of the G1/S transition may be influenced by a family of Cdk inhibitors that include p28Ick and the recently described inhibitors p21Cip1/Waf1/Cap20 and p16Ink4.
细胞周期蛋白依赖性激酶（Cdks）先前已被证明能驱动从酵母到人类等真核生物中的主要细胞周期转变。我们在此报告鉴定出一种28 kDa的蛋白质，即p28Ick（细胞周期蛋白依赖性激酶抑制剂），它能结合并抑制来自人类细胞的预先形成的Cdk/细胞周期蛋白复合物的激酶活性。p28的抑制活性在细胞周期中波动，在G1期达到最高水平，并在G1期和G0期停滞的细胞中积累。这些结果表明，G1/S转变的控制可能受到包括p28Ick以及最近描述的抑制剂p21Cip1/Waf1/Cap20和p16Ink4在内的一类Cdk抑制剂的影响。
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