Stadler M, Mayer A, Anke H, Sterner O
Lehrbereich Biotechnologie, Universität Kaiserslautern, Federal Republic of Germany.
Planta Med. 1994 Apr;60(2):128-32. doi: 10.1055/s-2006-959433.
In a screening for nematicidal activities in cultures of Basidiomycetes, cultures of Pleurotus pulmonarius and Hericium coralloides exhibited toxic effects towards the saprophytic nematode Caenorhabditis elegans. Subsequently S-coriolic acid (1), linoleic acid (2), p-anisaldehyde (3), p-anisyl alcohol (4), 1-(4-methoxyphenyl)-1,2-propanediol (5), and 2-hydroxy-(4'-methoxy)-propiophenone (6) were isolated from submerged cultures of P. pulmonarius. All compounds showed nematicidal activities towards C. elegans. The most active compounds were 1 and 2 with LD50 values between 5 and 10 ppm. Compounds 1, 4, and 5 have not been previously isolated from higher fungi, 6 is a new natural product. From cultures of H. coralloides, which exhibited both repellant and nematicidal effects, a nematicidal fatty acid mixture was obtained, containing linoleic acid, oleic acid, and palmitic acid as its main components.
在一项对担子菌培养物杀线虫活性的筛选中，肺形侧耳和珊瑚状猴头菌的培养物对腐生线虫秀丽隐杆线虫表现出毒性作用。随后，从肺形侧耳的深层培养物中分离出了S-科立酸（1）、亚油酸（2）、对茴香醛（3）、对茴香醇（4）、1-（4-甲氧基苯基）-1,2-丙二醇（5）和2-羟基-（4'-甲氧基）-苯丙酮（6）。所有化合物对秀丽隐杆线虫均表现出杀线虫活性。活性最强的化合物是1和2，其半数致死剂量值在5至10 ppm之间。化合物1、4和5此前尚未从高等真菌中分离得到，6是一种新的天然产物。从既表现出驱避作用又表现出杀线虫作用的珊瑚状猴头菌培养物中，获得了一种杀线虫脂肪酸混合物，其主要成分包含亚油酸、油酸和棕榈酸。
