Kusano M, Koshino H, Uzawa J, Fujioka S, Kawano T, Kimura Y
Department of Agricultural Chemistry, Faculty of Agriculture, Tottori University, Japan.
Biosci Biotechnol Biochem. 2000 Dec;64(12):2559-68. doi: 10.1271/bbb.64.2559.
A new nematicidal alkaloid, peniprequinolone (1), together with the known alkaloids penigequinolones A and B (2a, 2b), 3-methoxy-4-hydroxy-4-(4'-methoxyphenyl)quinolinone (3), and 3-methoxy-4,6-dihydroxy-4-(4'-methoxyphenyl)quinolinone (4), were isolated from Penicillium cf. simplicissimum (Oudemans) Thom. Cyclopenin (5) and a compound (6a/6b) structurally related to cyclopenin also were isolated from the fungus, and their structures were established by spectroscopic analysis. The biological activities of 1, 2, 3, 4, and 5 were examined by a bioassay with root-lesion nematodes.
从近似简青霉（Oudemans）Thom中分离出一种新的杀线虫生物碱青霉前喹诺酮（1），以及已知生物碱青霉喹诺酮A和B（2a、2b）、3-甲氧基-4-羟基-4-（4'-甲氧基苯基）喹啉酮（3）和3-甲氧基-4,6-二羟基-4-（4'-甲氧基苯基）喹啉酮（4）。还从该真菌中分离出环青霉素（5）和一种与环青霉素结构相关的化合物（6a/6b），并通过光谱分析确定了它们的结构。通过对根结线虫的生物测定研究了1、2、3、4和5的生物活性。
