Heinrich U, Roller M, Pott F
Fraunhofer-Institut für Toxikologie und Aerosolforschung, Hannover, Germany.
Toxicol Lett. 1994 Jun;72(1-3):155-61. doi: 10.1016/0378-4274(94)90023-x.
Female Wistar rats were exposed to coal tar/pitch condensation (CTP) aerosol containing either 20 or 46 micrograms/m3 benzo(a)pyrene (BaP) among other polycyclic aromatic hydrocarbons (PAH) 17 h/day and 5 days/week for 10 or 20 months followed by a clean air period of up to 20 or 10 months, respectively. Based on the inhaled BaP, given as BaP exposure concentration multiplied by the total exposure time, the cumulative dose of inhaled BaP of the 4 exposure groups was 71, 142, 158 and 321 mg BaP/m3 x h and the corresponding lung tumour rates were 4.2, 33.3, 38.9 and 97.2%. There was no lung tumour in the control group. Using the US Environmental Protection Agency (EPA) linearized multistage model, the lifetime lung tumour risk for rats exposed to 1 microgram/m3 BaP as a constituent of a complex PAH mixture may be 2% or correspondingly 2 per 100,000 with a BaP concentration of 1 ng/m3. The estimation of the unit lung cancer risk for BaP based on epidemiological data from coking plants was 7-9%.
将雌性Wistar大鼠暴露于含有20或46微克/立方米苯并(a)芘（BaP）以及其他多环芳烃（PAH）的煤焦油/沥青冷凝物（CTP）气溶胶中，每天暴露17小时，每周暴露5天，持续10或20个月，随后分别进入长达20或10个月的清洁空气期。根据吸入的BaP（以BaP暴露浓度乘以总暴露时间计算），4个暴露组吸入BaP的累积剂量分别为71、142、158和321毫克BaP/立方米·小时，相应的肺肿瘤发生率分别为4.2%、33.3%、38.9%和97.2%。对照组未出现肺肿瘤。使用美国环境保护局（EPA）的线性化多阶段模型，作为复杂PAH混合物成分暴露于1微克/立方米BaP的大鼠终生肺肿瘤风险可能为2%，或相应地，BaP浓度为1纳克/立方米时每100,000中有2例。基于焦化厂的流行病学数据对BaP的单位肺癌风险估计为7 - 9%。
