La Thangue N B
Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, London, UK.
Trends Biochem Sci. 1994 Mar;19(3):108-14. doi: 10.1016/0968-0004(94)90202-x.
During the cell cycle, the transcription of certain genes is integrated with cell-cycle progression, thus providing an important level of control. In mammalian cells, DRTF1/E2F is a transcription activity comprising a group of related heterodimeric transcription factors that function in this integration process. The primary molecules involved in generating the afferent signals that converge on DRTF1/E2F belong to a class of proteins, exemplified by the retinoblastoma tumour suppressor gene product, whose activities are, in turn, regulated by cyclin-dependent kinases. The transcriptional activity of DRTF1/E2F is therefore regulated through a pathway that links the machinery of the cell cycle to the transcription apparatus. As such, it is likely to play a pivotal role in regulating cell-cycle progression.
在细胞周期中，某些基因的转录与细胞周期进程相整合，从而提供了一个重要的调控层面。在哺乳动物细胞中，DRTF1/E2F是一种转录活性物质，由一组相关的异二聚体转录因子组成，在这一整合过程中发挥作用。参与产生汇聚于DRTF1/E2F的传入信号的主要分子属于一类蛋白质，以视网膜母细胞瘤肿瘤抑制基因产物为例，其活性又受细胞周期蛋白依赖性激酶的调控。因此，DRTF1/E2F的转录活性是通过一条将细胞周期机制与转录装置联系起来的途径来调控的。正因如此，它可能在调节细胞周期进程中起关键作用。
