Ohta N, Fukase S, Aoyagi M, Koike Y, Fukase Y, Sendo F
Department of Otolaryngology, Yamagata University School of Medicine, Japan.
Acta Otolaryngol Suppl. 1994;511:214-7. doi: 10.3109/00016489409128335.
The previous paper demonstrated that tonsillar cells cultured in vitro in the presence or absence of a streptococcal preparation, OK-432, produce factors that activate various neutrophil functions. In the present study, examination was made of the factor productivity of tonsillar cells from patients with chronic tonsillitis of varying severity, and palmoplantar pustulosis (PPP). Tonsillar cells from patients with severe tonsillitis and PPP incubated with culture medium alone produced a much greater amount of active factors compared with those from patients with mild tonsillitis. When tonsillar cells were incubated in the presence of OK-432, augmentation in factor production by the addition of OK-432 was less in former than latter cases, suggesting that factor production from tonsils correlates with the course of inflammation in this organ.
上一篇论文表明，在有或没有链球菌制剂OK-432存在的情况下体外培养的扁桃体细胞会产生激活各种中性粒细胞功能的因子。在本研究中，对不同严重程度的慢性扁桃体炎患者以及掌跖脓疱病（PPP）患者的扁桃体细胞的因子产生能力进行了检测。与轻度扁桃体炎患者的扁桃体细胞相比，单独用培养基培养的重度扁桃体炎和PPP患者的扁桃体细胞产生的活性因子数量要多得多。当扁桃体细胞在OK-432存在的情况下进行培养时，前者因添加OK-432而导致的因子产量增加幅度小于后者，这表明扁桃体产生因子的能力与该器官的炎症进程相关。
