Funahashi K, Tsujita K, Miki T, Koike J, Takatsuki M, Kubota S, Watanabe M, Yanagita K, Yoshio T
1st Dept. of Surgery, School of Medicine, Toho University.
Gan To Kagaku Ryoho. 1994 May;21 Suppl 1:47-51.
We studied the relationship between intratumoral DNA heterogeneity and clinicopathological findings in 85 colorectal cancers. DNA ploidy was analyzed in 5 specimens from different sites of each tumor. When the difference in the DNA index (D.I) between several peaks in the same tumor was more than 0.1, the tumor was considered to consist of heterogeneous subpopulations with different DNA clones. DNA heterogeneity was found in 34 cases (40.0%). There was no relationship between DNA heterogeneity and depth of tumor invasion, lymph node metastasis or stage. The incidence of heterogeneity was significantly higher in the tumor with lower differentiation, liver metastasis or vessel invasion.
我们研究了85例结直肠癌肿瘤内DNA异质性与临床病理特征之间的关系。对每个肿瘤不同部位的5个标本进行DNA倍体分析。当同一肿瘤中几个峰之间的DNA指数（D.I）差异大于0.1时，该肿瘤被认为由具有不同DNA克隆的异质性亚群组成。34例（40.0%）发现DNA异质性。DNA异质性与肿瘤浸润深度、淋巴结转移或分期之间无相关性。在低分化、肝转移或血管侵犯的肿瘤中，异质性的发生率显著更高。
