Oelschläger H, Hellwich K H, Rothley D
Institut für Pharmazeutische Chemie, Johann Wolfgang Goethe-Universität Frankfurt a.M.
Arch Pharm (Weinheim). 1994 Apr;327(4):261-5. doi: 10.1002/ardp.19943270412.
rac-2 described as a metabolite of rac-1 was synthesized in four steps starting with rac-3. Partial dehalogenation occurs with LiAlH4. A new structure assignment of the resulting stereoisomers resulted from NMR spectroscopy. After oral administration of rac-1 in multiple dose studies to volunteers, rac-2 could not be detected within the limitations of sensitivity of HPLC (UV-detector) in plasma or in urine.
rac - 2被描述为rac - 1的一种代谢产物，它以rac - 3为起始原料，经四步合成。用氢化铝锂进行部分脱卤反应。通过核磁共振光谱法对所得立体异构体进行了新的结构归属。在对志愿者进行的多剂量研究中口服rac - 1后，在血浆或尿液中，在高效液相色谱（紫外检测器）的灵敏度限制范围内未检测到rac - 2。
