Radostina A I, Kharchenko M N
Arkh Patol. 1994 Jan-Feb;56(1):65-70.
Mice of the strain C57BL/KsJ db+/db+ with a genetically predetermined diabetes mellitus type II were used. Experimental inflammation was produced by a subcutaneous administration of celloidin globules. Less developed synthetic and secretory apparatus and a decrease of cytoplasmic microprocesses formation are observed in the macrophages at both early (1 day) and late (14 days) periods in the diabetic animals. Besides that, less total size of the lysosomal apparatus at early periods and overloading of the cytoplasm with a non-degraded phagocytized material at late periods are observed in diabetic mice. This is considered as a morphological basis of the mononuclear phagocyte function decrease in diabetes mellitus.
使用具有遗传预定的II型糖尿病的C57BL/KsJ db+/db+品系小鼠。通过皮下注射火棉胶小球产生实验性炎症。在糖尿病动物的早期（1天）和晚期（14天），巨噬细胞中观察到合成和分泌装置发育较差以及细胞质微突起形成减少。除此之外，在糖尿病小鼠中，早期溶酶体装置的总体积较小，晚期细胞质中存在未降解的吞噬物质过载现象。这被认为是糖尿病中单核吞噬细胞功能下降的形态学基础。
