大鼠对东莨菪碱诱导的厌饮的巴甫洛夫式抑制性条件作用及耐受性逆转
Pavlovian inhibitory conditioning and tolerance-reversal to scopolamine-induced adipsia in rats.
作者信息
Vila J, Miranda F
机构信息
División de Estudios de Posgrado, Escuela Nacional de Estudios Profesionales Iztacala, Autonomous University of Mexico, Tlalnepantla, Mexico.
出版信息
Behav Neural Biol. 1994 Mar;61(2):177-80. doi: 10.1016/s0163-1047(05)80072-x.
In the present experiment the effect of a conditioned inhibitory stimulus on tolerance to scopolamine-induced adipsia was evaluated. Long-Evans rats were injected with 0.6 mg/kg scopolamine bromidrate in the presence of a tone or a noise, and physiological saline with a compound tone-odor. A summation test with the compound stimulus noise-odor showed a tolerance reversal effect to scopolamine adipsic effects in tolerant subjects. This reduction of tolerance was similar to adipsia produced by the first scopolamine administration, only when the odor stimulus was present. However, the inhibitory stimulus alone has no effect upon water intake. Results confirmed that a Pavlovian conditioned inhibition procedure can reduce conditioned tolerance to a drug.
在本实验中，评估了条件性抑制刺激对东莨菪碱诱导的厌水症耐受性的影响。在出现纯音或噪音的情况下，给长 Evans 大鼠注射 0.6 mg/kg 的氢溴酸东莨菪碱，并用复合音 - 气味给予生理盐水。对复合刺激噪音 - 气味进行的总和测试显示，在耐受的实验对象中，对东莨菪碱厌水效应的耐受性出现了逆转。只有当气味刺激存在时，这种耐受性的降低才与首次给予东莨菪碱所产生的厌水症相似。然而，单独的抑制性刺激对水的摄入量没有影响。结果证实，巴甫洛夫条件性抑制程序可以降低对药物的条件耐受性。
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