Dietrich P Y, Farace F, Caignard A, Escudier B, Triebel F
Unité d'immunothérapie, Institut Gustave-Roussy, Villejuif, France.
Bull Cancer. 1993 Jul;80(7):584-600.
The use of the immune system for the treatment of cancer is still debated. Recent advances in antigen presentation and recognition mechanisms, and the characterization of tumor-specific antigens generating a T cell response are crucial steps for the stimulation of research in this direction. These advances should allow the development of selective immunotherapy, either passive (infusion of lymphocytes with specific recognition of autologous tumor) or active (vaccination), and the evaluation of this new approach in cancer treatment strategies.
利用免疫系统治疗癌症仍存在争议。抗原呈递和识别机制的最新进展,以及产生T细胞反应的肿瘤特异性抗原的特征,是推动该方向研究的关键步骤。这些进展应能促进选择性免疫疗法的发展,包括被动免疫疗法(输注对自体肿瘤具有特异性识别能力的淋巴细胞)或主动免疫疗法(接种疫苗),并能在癌症治疗策略中评估这种新方法。