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[一种复合钴化合物作为氰化物解毒剂的应用]

[The use of a complex cobalt compound as a cyanide antidote].

作者信息

Bovykin B A

出版信息

Eksp Klin Farmakol. 1994 Mar-Apr;57(2):57-60.

PMID:8205053
Abstract

The medical effect of the cobalt (III) complex compound [Co(DH)2(H2O)2]Cl poisoning by potassium cyanide has been experimentally found. The poisoning has been caused by intravenous potassium cyanide, 1 mg/kg. The aqueous solution of the complex was added the same to cyanide in doses of 40 and 80 mg/kg. The poison and antidote effects were controlled by bioelectrical tests of the brain and heart. The advantage of the preparation is its direct interaction with cyanide and significantly lower doses as compared with the well-known anticyanide antidotes.

摘要

已通过实验发现钴(III)配合物[Co(DH)₂(H₂O)₂]Cl 被氰化钾中毒后的医学效应。中毒是由静脉注射 1 mg/kg 的氰化钾引起的。将该配合物的水溶液以 40 和 80 mg/kg 的剂量添加到氰化物中。通过大脑和心脏的生物电测试来控制中毒和解毒效果。该制剂的优点是它与氰化物直接相互作用,并且与著名的抗氰解毒剂相比剂量显著更低。

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