Candeias L P, Stratford M R, Wardman P
Cancer Research Campaign Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, UK.
Free Radic Res. 1994 Apr;20(4):241-9. doi: 10.3109/10715769409147520.
Hypochlorous acid reacts with the model iron(II) complex, ferrocyanide (Fe(CN)6(4-)) in aqueous solution with the rate constant 220 +/- 15 dm3 mol-1 s-1. Free hydroxyl radicals are formed in this reaction in 27% yield as shown by the hydroxylation of benzoate to give a product distribution identical to that of free (radiolytically generated) hydroxyl radicals. This reaction is three orders of magnitude faster than the analogous reaction involving hydrogen peroxide (the Fenton reaction), suggesting that the hypochlorous acid generated by activated neutrophils may be a source of hydroxyl radicals.
次氯酸与模型亚铁络合物亚铁氰化物（Fe(CN)₆⁴⁻）在水溶液中发生反应，反应速率常数为220±15 dm³·mol⁻¹·s⁻¹。该反应中以27%的产率生成了游离羟基自由基，这通过苯甲酸酯羟基化得到与游离（辐射产生的）羟基自由基相同的产物分布得以证明。此反应比涉及过氧化氢的类似反应（芬顿反应）快三个数量级，这表明活化的中性粒细胞产生的次氯酸可能是羟基自由基的一个来源。
