Wardman P, Candeias L P
Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, Middlesex, United Kingdom.
Radiat Res. 1996 May;145(5):523-31.
In 1876, Fenton described a colored product obtained on mixing tartaric acid with hydrogen peroxide and a low concentration of a ferrous salt. Full papers in 1894 and 1896 showed the product was dihydroxymaleic acid. Haber, Weiss and Willstätter proposed in 1932-1934 the involvement of free hydroxyl radicals in the iron(II)/hydrogen peroxide system, and Baxendale and colleagues around 1950 suggested that superoxide reduces the iron(III) formed on reaction, explaining the catalytic nature of the metal. Since Fridovich and colleagues discovered the importance of superoxide dismutase in 1968, numerous studies have sought to explain the deleterious effects of cellular oxidative stress in terms of superoxide-driven Fenton chemistry. There remain questions concerning the involvement of free hydroxyl radicals or reactions of metal/oxo intermediates. However, these outstanding questions may obscure a wider appreciation of the importance of Fenton chemistry involving hypohalous acids rather than hydrogen peroxide as the oxidant.
1876年，芬顿描述了一种将酒石酸与过氧化氢及低浓度亚铁盐混合时得到的有色产物。1894年和1896年发表的完整论文表明该产物是二羟基马来酸。哈伯、魏斯和维尔斯泰特在1932年至1934年提出在铁（II）/过氧化氢体系中存在游离羟基自由基，而巴赞代尔及其同事在1950年左右提出超氧化物会还原反应过程中生成的铁（III），这解释了金属的催化性质。自1968年弗里多维奇及其同事发现超氧化物歧化酶的重要性以来，众多研究试图从超氧化物驱动的芬顿化学反应角度解释细胞氧化应激的有害影响。关于游离羟基自由基的参与或金属/氧代中间体的反应仍存在问题。然而，这些悬而未决的问题可能会妨碍人们更广泛地认识到涉及次卤酸而非过氧化氢作为氧化剂的芬顿化学反应的重要性。
