Blood Press. 1993 Sep;2(3):166-82. doi: 10.3109/08037059309077548.
Sleep disordered breathing has increasingly been recognised as a frequent cause of ill-health in the community. Moderate or severe forms of the most common condition, obstructive sleep apnea (OSA), occur in up to 12% of the adult male population. A substantial body of literature has been published on the potential relationship between OSA and cardiovascular disease. In particular, OSA has been associated with cardiac failure, stroke, myocardial infarction and hypertension. Part of this association may be explained by other confounders, mainly obesity, which is common in OSA patients. The present review was prepared following a workshop aimed to critically review available scientific evidence suggesting that hypertension is a direct consequence of OSA. In addition, pathophysiologic mechanisms that may be involved in the relationship between OSA and cardiovascular disease, particularly brief intermittent elevation of blood pressure and sustained systemic hypertension, are discussed.
睡眠呼吸障碍日益被认为是社区中健康不良的常见原因。最常见的病症即阻塞性睡眠呼吸暂停（OSA）的中度或重度形式，在成年男性人群中发生率高达12%。关于OSA与心血管疾病之间的潜在关系，已经发表了大量文献。特别是，OSA与心力衰竭、中风、心肌梗死和高血压有关。这种关联的部分原因可能由其他混杂因素解释，主要是肥胖，这在OSA患者中很常见。本综述是在一次研讨会之后编写的，该研讨会旨在批判性地审视现有科学证据，这些证据表明高血压是OSA的直接后果。此外，还讨论了可能参与OSA与心血管疾病关系的病理生理机制，特别是血压的短暂间歇性升高和持续性全身性高血压。
