Lalonde R
Hôtel-Dieu Hospital, Neurology Service, Montreal, Que., Canada.
Brain Res. 1994 Mar 14;639(2):351-3. doi: 10.1016/0006-8993(94)91753-1.
Lurcher mutant mice, characterized by degeneration of the olivo-cerebellar system, were evaluated in two tests of motor coordination: the inclined screen test and the tilted platform test. Lurcher mutants were not impaired, in comparison to normal littermate controls, in the inclined screen test. In the tilted platform test, lurcher mutants fell more quickly than normal mice. However, with repeated testing, the amount of time spent on the platform by lurcher mutants and controls increased at the same rate within a 3 day period. These results demonstrate that lurcher mutants, although ataxic, have spared motor capabilities. In a test where motor deficits occurred, rapid improvement was seen. Thus, in spite of massive cerebellar degeneration, there was no evidence of a decreased rate in motor learning.
以橄榄小脑系统退化为特征的蹒跚突变小鼠，在两项运动协调性测试中接受了评估：倾斜屏幕测试和倾斜平台测试。与正常同窝对照相比，蹒跚突变小鼠在倾斜屏幕测试中没有受损。在倾斜平台测试中，蹒跚突变小鼠比正常小鼠更快掉落。然而，经过反复测试，蹒跚突变小鼠和对照在平台上花费的时间量在3天内以相同的速度增加。这些结果表明，蹒跚突变小鼠尽管存在共济失调，但仍保留了运动能力。在出现运动缺陷的测试中，可以看到快速改善。因此，尽管小脑发生了大量退化，但没有证据表明运动学习速率下降。
