Lalonde R, Bensoula A N, Filali M
Université de Nancy 1, Laboratoire de Biologie et Physiologie du Comportement, URA CNRS 1293, Vandoeuvre-les-Nancy, France.
Neurosci Res. 1995 Jul;22(4):423-6. doi: 10.1016/0168-0102(95)00916-h.
Lurcher mutant mice, characterized by degeneration of cerebellar granule and Purkinje cells, were compared to normal littermate controls in a rotorod test, consisting of a wheel turning at constant speed which required on the part of the animal postural adjustments in order to maintain equilibrium. Identical baseline rates for the two groups were assured by changing the speed and size of the rotating rod. Although both groups were able to learn the task, the fall latencies of normal mice exceeded those of lurchers. These results indicate that cerebellar cortical atrophy does not abolish this form of sensorimotor learning. However, brain-damaged animals are unable to reach the same level of performance as normal animals. In contrast to the results in lurcher mutants, no sensorimotor learning was displayed by hot-foot mutants and staggerer mutants.
蹒跚突变小鼠的特征是小脑颗粒细胞和浦肯野细胞退化，在转棒试验中，将其与正常同窝对照小鼠进行比较。转棒试验中，轮子以恒定速度转动，动物需要进行姿势调整以保持平衡。通过改变旋转棒的速度和大小，确保两组的初始速率相同。虽然两组都能够学会这项任务，但正常小鼠的掉落潜伏期超过了蹒跚突变小鼠。这些结果表明，小脑皮质萎缩并不会消除这种形式的感觉运动学习。然而，脑损伤动物无法达到与正常动物相同的表现水平。与蹒跚突变小鼠的结果相反，热足突变小鼠和蹒跚突变小鼠没有表现出感觉运动学习。
