Kowitz G M, Nathoo S A, Rustogi K N, Chmielewski M B, Liang L J, Wong R
University of California, Los Angeles, School of Dentistry.
Compend Suppl. 1994(17):S646-51.
A 2-week, three-cell study was conducted to evaluate the tooth-whitening efficacy of the Colgate Platinum Professional Toothwhitening System vs Rembrandt Gel Plus (a regimen of products consisting of a 10% carbamide peroxide gel, a whitening toothpaste, and a mouthrinse), and a placebo paste. Seventy subjects completed this parallel, single-blind, three-compartment, randomized clinical study. The subjects were balanced into two groups based on a minimal shade of A3 on the Vita shade guide and assigned a product. The duration of product usage was 1 hour twice daily for 2 weeks. Change in tooth color was measured by reflectance spectroscopy using a colorimeter. The readings were taken in the L*, a*, b* color space at the initiation, at 1 week, and at 2 weeks of the study. Calculation of color change (delta E) was performed using the color difference equation established by the Commission Internationale de L'Eclairage. Visual evaluation of shade changes was performed using the Vita shade guide. Results from this clinical study showed that Colgate Platinum was 77.7% more effective at tooth whitening after 1 week and 41.8% more effective after 2 weeks of treatment vs the Rembrandt regimen. Results showed that the Colgate product is significantly superior vs Rembrandt at increasing tooth whiteness (increase in delta E). Shade guide changes showed an overall improvement of 7.08 Vita tabs for the Colgate product and 5.12 Vita tabs for the Rembrandt regimen.
进行了一项为期两周的三细胞研究，以评估高露洁铂金装专业牙齿美白系统与瑞姆布兰特凝胶加强版（一种由10%过氧化脲凝胶、美白牙膏和漱口水组成的产品方案）以及安慰剂糊剂的牙齿美白效果。70名受试者完成了这项平行、单盲、三室、随机临床研究。根据Vita比色板上最小色度A3将受试者均衡分为两组，并分配一种产品。产品使用时间为每天两次，每次1小时，共2周。使用色度计通过反射光谱法测量牙齿颜色变化。在研究开始时、第1周和第2周在L*、a*、b*颜色空间中进行读数。使用国际照明委员会建立的色差方程计算颜色变化（ΔE）。使用Vita比色板对色度变化进行视觉评估。这项临床研究的结果表明，与瑞姆布兰特方案相比，高露洁铂金装在治疗1周后牙齿美白效果高出77.7%，在治疗2周后高出41.8%。结果表明，在增加牙齿白度（ΔE增加）方面，高露洁产品明显优于瑞姆布兰特。比色板变化显示，高露洁产品整体改善了7.08个Vita色阶，瑞姆布兰特方案改善了5.12个Vita色阶。
