Micheletti L, Barbero M, Preti M, Zanotto Valentino M C, Chiringhello B, Pippione M
Institute of Gynecology and Obstetrics, Chair University of Turin, Italy.
Eur J Gynaecol Oncol. 1994;15(1):70-4.
The authors reviewed 21 cases of "mild vulvar atypia" diagnosed from 1981 to 1990. The first 16 cases were diagnosed as hyperplastic dystrophy with mild atypia according to the 1976 ISSVD Classification of Vulvar Disease, while the last five cases were diagnosed as vulvar intraepithelial neoplasia grade I (VIN I). The review of the specimens was made by the same pathologist who gave the initial diagnosis and by a dermatopathologist unaware of the initial diagnosis. Both reviewers used the 1986 and 1989 ISSVD terminologies. The presence of "mild atypia" was confirmed in only four of the 21 specimens, that is in 19% of the cases, and two of them were found in the context of patients suffering from a lichen planus. These findings show that the diagnosis of mild atypia in vulvar tissues is a challenge and that mild vulvar atypia cannot be automatically considered a VIN I.
作者回顾了1981年至1990年间诊断的21例“轻度外阴异型增生”病例。根据1976年国际外阴疾病研究学会（ISSVD）的外阴疾病分类，前16例被诊断为伴有轻度异型增生的增生性营养不良，而后5例被诊断为外阴上皮内瘤变I级（VIN I）。标本复查由最初做出诊断的同一位病理学家以及一位不知道最初诊断结果的皮肤病理学家进行。两位复查者均采用1986年和1989年ISSVD的术语。21份标本中仅有4份证实存在“轻度异型增生”，即19%的病例，其中2例出现在扁平苔藓患者中。这些结果表明，外阴组织中轻度异型增生的诊断具有挑战性，且轻度外阴异型增生不能自动被视为VIN I。
