Jungnickel B, Rapoport T A, Hartmann E
Max-Delbrück Center for Molecular Medicine, Berlin-Buch, Germany.
FEBS Lett. 1994 Jun 6;346(1):73-7. doi: 10.1016/0014-5793(94)00367-x.
Protein transport across the endoplasmic reticulum membrane in eukaryotes and across the cytoplasmic membrane in bacteria have turned out to be highly related. The core component of the translocation apparatus is the Sec61/SecYp complex; at least two of its subunits are conserved in evolution. The Sec61/SecYp complex is involved in both co- and post-translational transport pathways. The two modes require probably distinct additional components.
真核生物中蛋白质跨内质网膜的转运以及细菌中蛋白质跨细胞质膜的转运已被证明高度相关。转运装置的核心组件是Sec61/SecYp复合体；其至少两个亚基在进化过程中是保守的。Sec61/SecYp复合体参与共翻译和翻译后转运途径。这两种模式可能需要不同的额外组件。
