2,4-二氯苯氧乙酸（2,4-D）致命过量中毒

Fatal overdose of 2,4-dichlorophenoxyacetic acid (2,4-D).

作者信息

Keller T, Skopp G, Wu M, Aderjan R

机构信息

Institute for Forensic Medicine, University of Heidelberg, Germany.

出版信息

Forensic Sci Int. 1994 Mar;65(1):13-8. doi: 10.1016/0379-0738(94)90295-x.

DOI:10.1016/0379-0738(94)90295-x

PMID:8206450

Abstract

An ingestion of an unknown quantity of U 46 D-Fluid (500 g dichlorophenoxyacetic acid/l) in a suicide is described. Although 2,4-dichlorophenoxyacetic acid (2,4 D) is widely used as a herbicide, intoxications are relatively rare. Quantitation of 2,4-D was performed by diethyl ether extraction from acidified samples (viscera) or by deproteinization (blood, plasma) with methanol before HPLC analysis. Postmortem concentrations of 2,4-D in body fluids and tissues are given. The proposed method resulted in a rapid procedure most useful in cases of deliberate poisoning with phenoxyacetic herbicides.

摘要

本文描述了一例自杀者摄入未知量U 46 D-液剂（500 g二氯苯氧基乙酸/升）的案例。尽管2,4-二氯苯氧基乙酸（2,4-D）被广泛用作除草剂，但中毒情况相对罕见。在进行高效液相色谱分析之前，通过用乙醚从酸化样品（内脏）中萃取或用甲醇进行脱蛋白处理（血液、血浆）来对2,4-D进行定量。文中给出了体液和组织中2,4-D的死后浓度。所提出的方法操作快速，在苯氧基乙酸类除草剂蓄意中毒的案例中非常有用。