醋酸氯替泼诺：在两种眼内炎症模型中与其他类固醇的比较。

Loteprednol etabonate: comparison with other steroids in two models of intraocular inflammation.

作者信息

Howes J F, Baru H, Vered M, Neumann R

机构信息

Pharmos Corporation, Alachua, Florida.

出版信息

J Ocul Pharmacol. 1994 Spring;10(1):289-93. doi: 10.1089/jop.1994.10.289.

DOI:10.1089/jop.1994.10.289

PMID:8207332

Abstract

Loteprednol etabonate (LE) is a novel steroid with a low tendency to raise IOP. It is metabolized in the eye to an inactive metabolite. The current study was undertaken to assess the intra-ocular anti-inflammatory activity of LE in two models of experimental uveitis in rabbits. In the endotoxin induced rabbit model, LE was effective at reducing measures of inflammation, but less so that either fluorometholone (FML) or dexamethasone. In the Freunds adjuvant chronic uveitis model, FML was also very effective with LE and dexamethasone showing similar activity. The data demonstrate that LE is effective at reducing intra-ocular inflammation.

摘要

氯替泼诺酯（LE）是一种新型类固醇，升高眼压的倾向较低。它在眼内代谢为无活性的代谢产物。本研究旨在评估LE在兔实验性葡萄膜炎的两种模型中的眼内抗炎活性。在内毒素诱导的兔模型中，LE在减轻炎症指标方面有效，但不如氟米龙（FML）或地塞米松有效。在弗氏佐剂慢性葡萄膜炎模型中，FML也非常有效，LE和地塞米松表现出相似的活性。数据表明LE在减轻眼内炎症方面有效。