Chamley L W, Pattison N S, McKay E J
Department of Immunology, Royal Liverpool University Hospital, UK.
J Reprod Immunol. 1993 Dec;25(3):209-20. doi: 10.1016/0165-0378(93)90064-o.
Anticardiolipin antibodies (aCL) were eluted from the placentae of four women with elevated serum levels of aCL, demonstrating that these antibodies are bound to affected placentae. Anticardiolipin antibodies bound to affected placentae were only of the IgG isotype and the level of aCL in placental eluates did not reflect serum levels. Anticardiolipin antibodies were not isolated from placental eluates of control normal pregnancies. beta 2-Glycoprotein 1, the anticardiolipin antibody cofactor, was present in the placental eluates from both control and antiphospholipid antibody (aPL) affected pregnancies and was localised in the syncytiotrophoblast by immunohistochemical analysis. Antinuclear antibodies were present in the placental eluates of 3 of the 4 patients with antiphospholipid antibody syndrome and were absent from the placental eluates of control pregnancies. The authors propose that anticardiolipin antibody binds directly to placental tissue, disrupting uteroplacental blood flow and/or transport through the villi.
从4名血清抗心磷脂抗体（aCL）水平升高的女性胎盘组织中洗脱得到了抗心磷脂抗体，这表明这些抗体与受累胎盘组织相结合。与受累胎盘组织结合的抗心磷脂抗体仅为IgG同种型，且胎盘洗脱液中的aCL水平并不反映血清水平。在对照正常妊娠的胎盘洗脱液中未分离出抗心磷脂抗体。抗心磷脂抗体辅助因子β2-糖蛋白1存在于对照妊娠和抗磷脂抗体（aPL）受累妊娠的胎盘洗脱液中，通过免疫组织化学分析定位在合体滋养层。4例抗磷脂抗体综合征患者中有3例的胎盘洗脱液中存在抗核抗体，而对照妊娠的胎盘洗脱液中不存在抗核抗体。作者提出，抗心磷脂抗体直接与胎盘组织结合，破坏子宫胎盘血流和/或通过绒毛的转运。
