van Beek E J, Büller H R, Brandjes D P, Rutten G C, ten Cate J W
Centre for Haemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Academic Medical Centre, Amsterdam, Netherlands.
Neth J Med. 1994 Feb;44(2):50-5.
To assess the diagnostic and therapeutic management of patients with clinically suspected pulmonary embolism.
A prospective survey of the management of patients with clinically suspected pulmonary embolism was carried out in two teaching hospitals in Amsterdam, without the knowledge of the attending physicians. Use and timing of lung scintigraphy and other tests for venous thromboembolism, therapeutic consequences and duration of hospitalization were evaluated.
Of 89 outpatients and 116 inpatients, 97% of patients underwent lung scintigraphy. Lung scan results were normal in 51% of outpatients and 20% of directly admitted patients; high probability in 10% and 22% and non-diagnostic in 39% and 58%, respectively. Twenty-two outpatients were subsequently admitted (1 normal, 9 high-probability and 12 non-high-probability lung scans). Pulmonary angiography and tests for deep vein thrombosis were performed in 7 (10%) and 21 (29%) of admitted patients with a non-diagnostic lung scan outcome, respectively. Of 138 admitted patients, 75 (54%) received heparin for 5 or more days. All patients with high-probability lung scans and none with a normal lung scan received long-term anticoagulants. Of patients with non-diagnostic lung scans, therapeutic decisions were mainly based on clinical grounds, and 44% were prescribed oral anticoagulants. The median duration of hospitalization was 6 days, 14 days and 13 days for patients with a normal lung scan, a non-diagnostic lung scan and a high-probability lung scan outcome, respectively.
Diagnostic delay in directly hospitalized patients results in anticoagulation of patients without pulmonary embolism and excessive hospitalization. Guidelines for the diagnostic management of patients with non-diagnostic lung scans are urgently required.
评估临床疑似肺栓塞患者的诊断和治疗管理情况。
在阿姆斯特丹的两家教学医院对临床疑似肺栓塞患者的管理进行前瞻性调查,主治医生并不知情。对肺闪烁显像及其他静脉血栓栓塞检查的使用和时机、治疗结果及住院时间进行了评估。
89名门诊患者和116名住院患者中,97%的患者接受了肺闪烁显像。门诊患者中51%、直接入院患者中20%的肺扫描结果正常;门诊患者中10%、直接入院患者中22%的扫描结果为高度可能;门诊患者中39%、直接入院患者中58%的扫描结果无法诊断。随后22名门诊患者入院(1名肺扫描正常,9名高度可能,12名非高度可能)。肺扫描结果无法诊断的入院患者中,分别有7名(10%)和21名(29%)接受了肺血管造影和深静脉血栓形成检查。138名入院患者中,75名(54%)接受了5天或更长时间的肝素治疗。所有肺扫描高度可能的患者以及肺扫描正常的患者中无一接受长期抗凝治疗。肺扫描结果无法诊断的患者中,治疗决策主要基于临床依据,44%的患者接受了口服抗凝药治疗。肺扫描正常、结果无法诊断和高度可能的患者住院时间中位数分别为6天、14天和13天。
直接住院患者的诊断延迟导致无肺栓塞患者接受抗凝治疗以及住院时间过长。迫切需要针对肺扫描结果无法诊断患者的诊断管理指南。