Yamaguchi Y, Kobayashi H
Research Laboratory, Zenyaku Kogyo Co., Ltd, Tokyo, Japan.
Neuropeptides. 1994 Mar;26(3):153-8. doi: 10.1016/0143-4179(94)90124-4.
The effects of vasoactive intestinal peptide (VIP) on spatial cognitive deficits induced in the rat by injections of scopolamine were examined in a radial arm maze. A single intraperitoneal (i.p.), subcutaneous (s.c.) or intracerebroventricular (i.c.v.) injection of VIP inhibited the reduction in the number of initial correct responses in rats with scopolamine-induced amnesia. The inhibition was associated with a bell-shaped dose-response curve. Thus, VIP appears to have an ameliorating effect on spatial cognitive deficits induced by scopolamine in the rat.
在放射状臂迷宫中研究了血管活性肠肽（VIP）对东莨菪碱注射诱导的大鼠空间认知缺陷的影响。单次腹腔内（i.p.）、皮下（s.c.）或脑室内（i.c.v.）注射VIP可抑制东莨菪碱诱导失忆的大鼠初始正确反应次数的减少。这种抑制作用与钟形剂量反应曲线相关。因此，VIP似乎对东莨菪碱诱导的大鼠空间认知缺陷具有改善作用。
