Pitsikas N, Algeri S
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Pharmacol Biochem Behav. 1992 Nov;43(3):949-51. doi: 10.1016/0091-3057(92)90430-n.
The effects of the nootropic agent 4-hydroxy-2-oxopyrrolidinoacetamide (oxiracetam) on memory and performance impairments induced by scopolamine were evaluated in the Morris water maze task. No effect was seen on the performance of rats when treated with oxiracetam (30 mg/kg, IP) alone. Task performance of scopolamine (0.2 mg/kg, SC)-treated rats was impaired as compared to that of control animals. The behavioral deficits expressed in the task by scopolamine treatment were attenuated by the same dose of oxiracetam.
