Nikolaev E, Kaczmarek L
Nencki Institute of Experimental Biology, Warsaw, Poland.
Pharmacol Biochem Behav. 1994 Mar;47(3):757-9. doi: 10.1016/0091-3057(94)90186-4.
Nimodipine, a voltage-sensitive calcium channel blocker, has been suggested to be a procognitive drug. In the studies reported herein, we found that low doses of IP-injected nimodipine (0.5 and 0.05 mg/kg) impaired two-way active avoidance behavior. The acquisition phase of the training was the same for drug-treated and control animals. However, the nimodipine-injected rats achieved a significantly lower level of performance. The no-shock tests revealed much faster extinction of the learned behavior in drug-treated vs. control animals. These results could be interpreted as indicating learning-disruptive effects of nimodipine.
尼莫地平，一种电压敏感性钙通道阻滞剂，已被认为是一种促认知药物。在本文报道的研究中，我们发现腹腔注射低剂量的尼莫地平（0.5和0.05毫克/千克）会损害双向主动回避行为。药物处理组和对照组动物训练的习得阶段相同。然而，注射尼莫地平的大鼠的表现水平明显较低。无电击测试显示，与对照组动物相比，药物处理组动物习得行为的消退要快得多。这些结果可以解释为表明尼莫地平具有破坏学习的作用。
