Poplawsky A, Isaacson R L
Department of Psychology, Bloomsburg University of Pennsylvania 17815.
Behav Neural Biol. 1990 Jan;53(1):133-9. doi: 10.1016/0163-1047(90)90916-t.
Rats with large electrolytic lesions of the septal area were given the calcium channel antagonist nimodipine (70 micrograms/kg, ip) or its vehicle on the day of surgery and for 3 subsequent days. They were tested for emotionality and compared to control rats for 10 days beginning on the third day after surgery. Forty days after surgery all animals were trained in a two-way active avoidance task for 120 trials. Nimodipine reduced the hyperemotionality found after septal lesions as early as the first test day, and increased the rate of recovery toward control levels on subsequent days. Both septal-lesion groups exhibited more avoidance responses than controls, even though the intertrial crossings were enhanced only in rats with septal lesions that did not receive nimodipine.
在手术当天及随后3天，给患有大面积中隔区电解损伤的大鼠腹腔注射钙通道拮抗剂尼莫地平（70微克/千克）或其溶媒。从手术后第三天开始，对它们进行情绪测试，并与对照大鼠进行为期10天的比较。手术后40天，所有动物都接受双向主动回避任务训练，共进行120次试验。尼莫地平早在第一个测试日就减轻了中隔损伤后出现的过度情绪化，并在随后几天提高了恢复到对照水平的速率。两个中隔损伤组都比对照组表现出更多的回避反应，尽管只有未接受尼莫地平的中隔损伤大鼠的试验间穿越次数增加。
