Bogdahn U, Fröhlich T, Becker G, Krone A, Schlief R, Schürmann J, Jachimczak P, Hofmann E, Roggendorf W, Roosen K
Department of Neurology, University of Würzburg, Germany.
Radiology. 1994 Jul;192(1):141-8. doi: 10.1148/radiology.192.1.8208926.
To study the potential of contrast material-enhanced transcranial color-coded real-time sonography (TCCS) in detection of primary intracranial tumor vascularization.
Primary central nervous system (CNS) tumors in 28 patients were examined with TCCS before and during administration of a transpulmonary, stable, galactose, microparticle-based ultrasound (US) contrast agent. All patients underwent cranial computed tomography and magnetic resonance imaging; nine patients also underwent intraarterial digital subtraction angiography.
All lesions were hyperechoic on B-mode US scans except one grade 2 astrocytoma. The location and extent of hyperechoic lesions correlated well with findings on CT scans and MR images. After injection of contrast material, color Doppler flow signals were seen in nine of 14 low-grade lesions and 14 of 14 high-grade lesions. High-grade malignant tumors always had atypical arterial and venous Doppler spectra with irregular distribution of Doppler shift and signal intensities; these atypical flow patterns were also detected in some low-grade tumors.
In addition to depiction of primary CNS tumors in B-mode, contrast-enhanced TCCS enables evaluation of vascularization associated with tumor parenchyma.
研究对比剂增强经颅彩色编码实时超声检查（TCCS）在检测原发性颅内肿瘤血管化方面的潜力。
对28例原发性中枢神经系统（CNS）肿瘤患者在使用经肺、稳定、基于半乳糖微粒的超声（US）对比剂之前及期间进行TCCS检查。所有患者均接受了头颅计算机断层扫描和磁共振成像检查；9例患者还接受了动脉内数字减影血管造影检查。
除1例2级星形细胞瘤外，所有病变在B型超声扫描中均为高回声。高回声病变的位置和范围与CT扫描和磁共振图像的表现密切相关。注射对比剂后，14例低级别病变中有9例及14例高级别病变中有14例可见彩色多普勒血流信号。高级别恶性肿瘤总是具有非典型的动脉和静脉多普勒频谱，多普勒频移和信号强度分布不规则；在一些低级别肿瘤中也检测到了这些非典型血流模式。
除了在B型超声中显示原发性中枢神经系统肿瘤外，对比增强TCCS还能够评估与肿瘤实质相关的血管化情况。
