Corbally N, Grogan L, Keane M M, Devaney D M, Dervan P A, Carney D N
Department of Oncology, Mater Misericordiae Hospital, Dublin, Ireland.
Am J Clin Pathol. 1994 Jun;101(6):756-60. doi: 10.1093/ajcp/101.6.756.
The chromosomal translocation t(14;18)(q32;q21), which involves the bcl-2 oncogene, occurs in most follicular lymphomas. Recent evidence suggests that this translocation occurs in Hodgkin's disease, linking its cellular origin and oncogenesis to follicular non-Hodgkin's lymphomas. Using polymerase chain reaction, the authors examined both Hodgkin's disease (n = 60) and reactive lymph nodes (n = 34) for the presence of bcl-2/JH breakpoint fragments, which are indicative of the t(14;18) chromosomal translocation in the major breakpoint region of the bcl-2 gene. The translocation was detected in approximately 10% of both Hodgkin's disease and nonmalignant reactive lymph node cases. These results suggest the possibility that the translocation may occur in the reactive component of Hodgkin's disease and not in the putative malignant cells, the Reed-Sternberg cells. Furthermore, the detection of the translocation in reactive lymph nodes suggests that it may not be the primary factor in the oncogenesis of follicular lymphoma.
涉及bcl - 2癌基因的染色体易位t(14;18)(q32;q21)见于大多数滤泡性淋巴瘤。最近的证据表明，这种易位也见于霍奇金病，将其细胞起源和肿瘤发生与滤泡性非霍奇金淋巴瘤联系起来。作者使用聚合酶链反应检测了60例霍奇金病和34例反应性淋巴结中bcl - 2/JH断裂点片段的存在情况，这些片段指示bcl - 2基因主要断裂点区域的t(14;18)染色体易位。在大约10%的霍奇金病病例和非恶性反应性淋巴结病例中均检测到该易位。这些结果提示，该易位可能发生在霍奇金病的反应性成分中，而非假定的恶性细胞即里德-斯腾伯格细胞中。此外，在反应性淋巴结中检测到该易位表明，它可能不是滤泡性淋巴瘤肿瘤发生的主要因素。
