Crews W D, Bonaventura S, Rowe F B, Bonsie D
Central Virginia Training Center, Lynchburg 24505.
Res Dev Disabil. 1993 Jul-Aug;14(4):331-40. doi: 10.1016/0891-4222(93)90026-g.
The cessation of long-term Naltrexone administration was investigated through a double-blind, placebo-controlled, withdrawal design in a 28-year-old, profoundly mentally retarded woman with a history of severe self-injurious behavior (SIB). The subject had previously exhibited a dramatic decrease in SIB subsequent to Naltrexone administration. At the end of 1 year of continuous drug treatment, the subject displayed a near-zero rate of SIB episodes. This near-zero rate continued through placebo and no-drug phases of the study and at 6-month (no-drug) follow-up. This trend suggests not only that Naltrexone may be effective in reducing SIB, but that long-term administration may produce durable results after treatment cessation. Findings are discussed in relation to the endogenous opioid system theories of SIB.
通过双盲、安慰剂对照、撤药设计，对一名28岁、患有严重自伤行为（SIB）病史的极重度智力障碍女性进行了长期纳曲酮给药停止的研究。该受试者此前在服用纳曲酮后自伤行为显著减少。在连续药物治疗1年后，该受试者的自伤行为发作率几乎为零。在研究的安慰剂和无药物阶段以及6个月（无药物）随访期间，这一几乎为零的发生率一直持续。这一趋势不仅表明纳曲酮可能对减少自伤行为有效，而且长期给药在停药后可能产生持久效果。结合自伤行为的内源性阿片系统理论对研究结果进行了讨论。
