Walters A S, Barrett R P, Feinstein C, Mercurio A, Hole W T
Brown University Program in Medicine, Emma Pendleton Bradley Hospital, East Providence, Rhode Island 02915.
J Autism Dev Disord. 1990 Jun;20(2):169-76. doi: 10.1007/BF02284716.
The endogenous opiate release theory of self-injurious behavior (SIB) was investigated through double-blind placebo-controlled administration of naltrexone hydrochloride (Trexan) to a 14-year-old autistic and mentally retarded male for treatment of severe SIB. Results yielded a marked decrease in SIB during two phases of active drug treatment, though SIB did not revert to originally observed placebo levels during a second placebo phase. An increase in social relatedness also was observed during phases of active drug treatment. Opiate theories of self-injury and the possible interrelationship of self-injury with pituitary-adrenal arousal and with social relatedness are discussed.
通过对一名14岁患有自闭症和智力障碍的男性进行盐酸纳曲酮（Trexan）的双盲安慰剂对照给药，以治疗严重的自伤行为（SIB），对自伤行为的内源性阿片释放理论进行了研究。结果显示，在两个积极药物治疗阶段，自伤行为显著减少，尽管在第二个安慰剂阶段，自伤行为并未恢复到最初观察到的安慰剂水平。在积极药物治疗阶段，还观察到社交相关性有所增加。本文讨论了自伤的阿片理论以及自伤与垂体-肾上腺唤醒和社交相关性之间可能的相互关系。
