Carlson G P
Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907-1334.
Res Commun Mol Pathol Pharmacol. 1994 Oct;86(1):111-7.
The esterification of fatty acids by ethanol via a nonoxidative pathway has been well documented and has been implicated in toxic effects in animals and humans. The administration of 1-butanol (1 ml/kg, ip) to rats resulted in the formation of butyl esters of palmitate, stearate and oleate in the liver but not in measurable quantities in lung or pancreas. 1-Pentanol (amyl alcohol) administration (0.25 ml/kg, ip) did not result in esterification of fatty acids in any tissue. The data suggest that chain length may be important in the ability of alcohols to esterify fatty acids in vivo.
乙醇通过非氧化途径对脂肪酸进行酯化作用已得到充分证明，并且这一过程与对动物和人类的毒性作用有关。给大鼠腹腔注射1-丁醇（1毫升/千克）后，肝脏中形成了棕榈酸、硬脂酸和油酸的丁酯，但在肺或胰腺中未检测到可测量的量。腹腔注射1-戊醇（戊醇）（0.25毫升/千克）未导致任何组织中的脂肪酸酯化。数据表明，链长可能对醇类在体内酯化脂肪酸的能力很重要。
