大鼠和家兔体内不同醇类对脂肪酸的体外酯化作用

In vitro esterification of fatty acids by various alcohols in rats and rabbits.

作者信息

Carlson G P

机构信息

Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907-1334.

出版信息

Toxicol Lett. 1994 Jan;70(1):57-61. doi: 10.1016/0378-4274(94)90144-9.

DOI:10.1016/0378-4274(94)90144-9

PMID:8310457

Abstract

The ability of six alcohols--1-propanol, 2-propanol, 1-butanol, 1-amyl alcohol, isoamyl alcohol and 1-octanol--to esterify fatty acids in vitro was determined in liver, lung and pancreas from rats and rabbits by incubating tissue homogenates with [14C]oleic acid and isolating and quantifying the esterified fatty acid. There was considerable variation in the amount of esterified fatty acid formed depending upon the alcohol. The relative rates of formation among the tissues were pancreas >> liver > lung. In view of the deleterious effects associated with the esters formed by ethanol, consideration must also be given to these other alcohols as well.

摘要

通过将组织匀浆与[14C]油酸一起孵育，并分离和定量酯化脂肪酸，测定了六种醇类——1-丙醇、2-丙醇、1-丁醇、1-戊醇、异戊醇和1-辛醇——在大鼠和兔子的肝脏、肺和胰腺中体外酯化脂肪酸的能力。根据醇类的不同，酯化脂肪酸的生成量有很大差异。各组织间酯化脂肪酸的相对生成速率为胰腺>>肝脏>肺。鉴于与乙醇形成的酯类相关的有害影响，也必须考虑这些其他醇类。