Vellenga C J, Pauwels E K, Bijvoet O L, Hosking D J
Radiol Clin (Basel). 1976;45(2-4):292-301.
Scintigraphic and roentgenological studies in 9 patients, treated for Paget's disease, were evaluated before and during treatment and related to the values of serum alkaline phosphatase. On the initial studies--before treatment--25 lesions were found on both scintigram and roentgenogram. One lesion--proven by biopsy--was only seen on the scintigram. The roentgenograms showed no changes during this period, ranging from 6-16 months, except for one lesion with dubious progression. The scintigrams, carried out using 99Tcm-EHDP, showed both a qualitative and quantitative improvement in 7 cases. The ratios of radionuclide accumulation in Pagetoid bone and normal bone corresponded well with the values of serum alkaline phosphatase. In 4 out of 9 cases, however, the scintigram still demonstrated pathologic uptake of radioactivity, while serum alkaline phosphatase levels had dropped to normal values. It is concluded that bone scintigraphy may be of value for the follow up of patients under treatment for Paget's disease.
对9例接受佩吉特病治疗的患者进行了闪烁扫描和X线检查，在治疗前和治疗期间进行了评估，并与血清碱性磷酸酶值相关联。在初始研究中——治疗前——在闪烁扫描图和X线片上均发现了25处病变。经活检证实的1处病变仅在闪烁扫描图上可见。在此期间（6至16个月），除1处病变有可疑进展外，X线片未见变化。使用99锝-亚甲基二膦酸盐（99Tcm-EHDP）进行的闪烁扫描显示，7例患者在定性和定量方面均有改善。畸形性骨炎骨和正常骨中放射性核素的蓄积率与血清碱性磷酸酶值非常吻合。然而，在9例患者中有4例，闪烁扫描图仍显示放射性摄取异常，而血清碱性磷酸酶水平已降至正常。结论是，骨闪烁扫描可能对佩吉特病治疗患者的随访有价值。
