Wellman H N, Schauwecker D, Robb J A, Khairi M R, Johnston C C
Clin Orthop Relat Res. 1977(127):55-62.
Experiences in sue of skeletal scintimaging, primarily with 99mTc EHDP, is reported in 108 patients with Paget's disease. The results are compared with other reports and suggest that the mean age of this sample at the time of initial diagnosis and study is somewhat younger than patients in series reported in the literature. In correlation of scintimaging with skeletal radiography only approximately 67% of lesions are seen with the latter. Lesions seen only on scintimaging primarily are associated with early symptomatic lesions and lesions seen only on radiography with older sclerotic "burned out" type lesions. Scintimaging reveals a relatively low incidence of monostotic distribution of lesions, and is superior to skeletal radiography for diagnosis of metastatic bone disease. Qualitative skeletal scintimaging is valuable for objective assessments of therapeutic management by new modes of therapy while clinical radiography is not.
本文报道了108例佩吉特病患者使用骨骼闪烁成像的经验，主要使用的是99mTc EHDP。研究结果与其他报告进行了比较，表明该样本在初次诊断和研究时的平均年龄比文献报道系列中的患者略年轻。在闪烁成像与骨骼X线摄影的相关性方面，后者仅能发现约67%的病变。仅在闪烁成像上发现的病变主要与早期症状性病变相关，而仅在X线摄影上发现的病变则与较陈旧的硬化性“静止”型病变相关。闪烁成像显示病变单骨分布的发生率相对较低，在诊断骨转移疾病方面优于骨骼X线摄影。定性骨骼闪烁成像对于通过新治疗模式对治疗管理进行客观评估很有价值，而临床X线摄影则不然。
