Godfrey S, König P
Thorax. 1976 Apr;31(2):137-43. doi: 10.1136/thx.31.2.137.
Exercise-induced asthma (EIA) was provoked by standardized treadmill running for 6 minutes in 15 asthmatic children. The tests were carried out after the administration of a placebo, salbutamol, sodium cromoglycate, choline theophyllinate, and atrophine methonitrate aerosol in randomized fashion on different days. The mean post-exercise percent fall in peak expiratory flow rate was 45-2, 4-1, 19-6, 18-3, and 24-9 respectively. The proportion of children having significant amelioration of their EIA compared with those taking the placebo was 100% for salbutamol, 80% for cromoglycate and theophyllinate, and 60% for atropine. Salbutamol, choline theophyllinate, and atropine were bronchodilators at rest whereas cromoglycate was not, and the ability to suppress EIA was unrelated to bronchodilator effect. Even after bronchodilatation at rest, further broncho-dilatation occurred during the exercise period.
对15名哮喘儿童进行标准化跑步机跑步6分钟激发运动诱发性哮喘（EIA）。在不同日期以随机方式分别给予安慰剂、沙丁胺醇、色甘酸钠、胆茶碱和硝酸甲基阿托品气雾剂后进行测试。运动后呼气峰值流速平均下降百分比分别为45 - 2、4 - 1、19 - 6、18 - 3和24 - 9。与服用安慰剂相比，沙丁胺醇使EIA明显改善的儿童比例为100%，色甘酸钠和茶碱为80%，阿托品为60%。沙丁胺醇、胆茶碱和阿托品在静息时为支气管扩张剂，而色甘酸钠不是，抑制EIA的能力与支气管扩张作用无关。即使在静息时支气管扩张后，运动期间仍会进一步支气管扩张。
