Prime F J
J Int Med Res. 1979;7(5):428-33. doi: 10.1177/030006057900700517.
Using a randomized double-blind procedure, seventeen patients with chronic airways obstruction completed a placebo-controlled study to compare bronchodilator effects of single doses of choline theophyllinate 400 mg and salbutamol 4 mg. As determined by a range of spirometric measurements, the effects of the two drugs were remarkably similar and there were no statistically significant differences in any of the parameters measured. Both drugs produced highly significant differences in comparison with placebo response. Side-effects were mainly complaints of digital tremor; this was seen in four of the patients after salbutamol and in less pronounced form in two patients after choline theophyllinate.
采用随机双盲程序，17例慢性气道阻塞患者完成了一项安慰剂对照研究，以比较单剂量400毫克胆茶碱和4毫克沙丁胺醇的支气管扩张作用。通过一系列肺功能测量确定，两种药物的效果非常相似，所测的任何参数均无统计学显著差异。与安慰剂反应相比，两种药物均产生了高度显著的差异。副作用主要是手指震颤的主诉；沙丁胺醇治疗后4例患者出现这种情况，胆茶碱治疗后2例患者症状较轻。
