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[脂质过氧化物和血液流变学紊乱在缺血性心脏病发病机制及临床病程中的作用]

[The role of lipid peroxides and blood rheological disorders in the pathogenesis and clinical course of ischemic heart disease].

作者信息

Mingazetdinova L N, Zakirova A N, Lankin V Z

出版信息

Ter Arkh. 1993;65(8):12-5.

PMID:8211792
Abstract

Combined assessment of primary and secondary products of lipid peroxidation, functional activity of red cells has been conducted in 130 patients with ischemic heart disease running different courses. Lipid peroxidation was found enhanced both in the whole blood and red blood cells. Blood rheology got abnormal. It is shown that lipid peroxides are involved in damaging erythrocytic membrane structure and function, thus promoting the progression of ischemic heart disease.

摘要

对130例病程不同的缺血性心脏病患者进行了脂质过氧化初级和次级产物以及红细胞功能活性的联合评估。发现全血和红细胞中的脂质过氧化均增强。血液流变学出现异常。结果表明,脂质过氧化物参与破坏红细胞膜结构和功能,从而促进缺血性心脏病的进展。

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