Waldmann H, Cobbold S
Immunology Division, Department of Pathology, Cambridge, UK.
Trends Pharmacol Sci. 1993 May;14(5):143-8. doi: 10.1016/0165-6147(93)90198-s.
Monoclonal antibodies are potentially useful immunosuppressive agents. Short course of CD4/CD8 monoclonal antibody can be used to guide the immune system of experimental animals to accept organ grafts and to arrest autoimmunity. This reprogramming, reviewed by Herman Waldmann and Stephen Cobbold, is accompanied by potent T-cell dependent, 'infectious' regulatory mechanisms. A goal for therapeutic immunosuppression should be to understand and harness these innate immunoregulatory mechanisms.
单克隆抗体是潜在有用的免疫抑制剂。短期使用CD4/CD8单克隆抗体可用于引导实验动物的免疫系统接受器官移植并抑制自身免疫。赫尔曼·瓦尔德曼（Herman Waldmann）和斯蒂芬·科博尔德（Stephen Cobbold）回顾了这种重编程过程，它伴随着强大的T细胞依赖性“传染性”调节机制。治疗性免疫抑制的一个目标应该是理解并利用这些先天免疫调节机制。
