Wörtwein G, Mogensen J, Divac I
Institute of Neuropsychiatry, University of Copenhagen, Denmark.
Acta Neurobiol Exp (Wars). 1993;53(2):357-66.
Lesions of the medial prefrontal cortex strongly impaired rats' delayed alternation behaviour in a T-maze, both when the lesion was inflicted after the initial acquisition of the task and when the lesion was added after criterion performance had been reattained following an ablation of the parietal cortex. Lesions of the parietal cortex did not impair this behaviour, either when the parietal lesion was inflicted after the initial acquisition of the task or when it was added to a prefrontal lesion after criterion performance had been reattained. Combined, one stage, parietal and prefrontal lesions did not have stronger effect on delayed alternation than did prefrontal lesions alone. These results indicate that in spite of the strong anatomical connectivity between the prefrontal and parietal "association" cortex the latter is not necessary for the recovery of delayed alternation after prefrontal lesions. In comparison with the parietal cortex, the prefrontal cortex seems to be uniquely involved in mediation of delayed alternation.
内侧前额叶皮质损伤严重损害了大鼠在T迷宫中的延迟交替行为，无论是在任务最初习得后造成损伤，还是在顶叶皮质切除后重新达到标准表现后再添加损伤时。顶叶皮质损伤并未损害这种行为，无论是在任务最初习得后造成顶叶损伤，还是在重新达到标准表现后将其添加到前额叶损伤上时。总的来说，一步完成的顶叶和前额叶联合损伤对延迟交替行为的影响并不比单独的前额叶损伤更强。这些结果表明，尽管前额叶和顶叶“联合”皮质之间存在很强的解剖学连接，但在额叶损伤后延迟交替行为的恢复过程中，顶叶并非必需。与顶叶皮质相比，前额叶皮质似乎在延迟交替行为的调节中具有独特作用。
