Swartz C M, Breen K J
Department of Psychiatric Medicine, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354.
Am J Drug Alcohol Abuse. 1993;19(3):327-35. doi: 10.3109/00952999309001622.
In preparation for an exercise program in cocaine abusers maintained abstinent in a hospital setting (average 98.4 days), we measured resting serum creatine kinase (CK). Surprisingly, many were elevated. Further tests confirmed the observation. We measured 19 long abstinent cocaine abusers, 22 abstinent abusers of other substances, and a later group of 26 long abstinent cocaine abusers. While none of the other substance abusers showed elevated serum CK levels, 53 and 31% of the abstinent cocaine groups did (p = .000082 and .00041, respectively). All CK elevations were muscle derived; repeated sampling demonstrated stability. Cocaine abusers' CK showed a bimodal distribution: the lower bell curve approximated controls and the higher bell curve centered above normal range, at 400 U/L. Demographics did not influence the results. With complementary findings of impaired spatial motor performance, these persistent CK elevations suggest that a large minority of cocaine abusers maintain tendencies to coarse motor control and impulsive movements, and perhaps hyperactivity.
为了准备一项针对在医院环境中保持戒毒状态（平均98.4天）的可卡因滥用者的运动计划，我们测量了静息血清肌酸激酶（CK）。令人惊讶的是，许多人的该指标升高了。进一步的测试证实了这一观察结果。我们测量了19名长期戒毒的可卡因滥用者、22名戒除其他物质的滥用者以及后来的一组26名长期戒毒的可卡因滥用者。虽然其他物质滥用者中没有一人血清CK水平升高，但戒毒的可卡因组中分别有53%和31%的人出现了升高（p值分别为0.000082和0.00041）。所有CK升高均源自肌肉；重复采样显示结果稳定。可卡因滥用者的CK呈现双峰分布：较低的钟形曲线接近对照组，较高的钟形曲线以正常范围之上400 U/L为中心。人口统计学因素并未影响结果。结合空间运动表现受损的补充发现，这些持续的CK升高表明，很大一部分可卡因滥用者仍有粗略运动控制和冲动行为的倾向，甚至可能存在多动。
