Keighley M R, Burdon D W, Alexander-Williams J, Shinagawa N, Arabi Y, Thompson H, Youngs D, Bentley S, George R H
Lancet. 1978 Dec 2;2(8101):1165-7. doi: 10.1016/s0140-6736(78)92151-7.
241 patients who had gastrointestinal operations were studied prospectively. Postoperative diarrhoea occurred in 58 patients (24%) and was significantly more common after exposure to antibiotics. 9 patients (4%) had high titres of a neutralisable faecal toxin characteristic of pseudomembranous colitis. Toxigenic Clostridium difficile strains were isolated from the stools of all patients with neutralisable faecal toxin. If pseudomembranous colitis is defined as the presence of neutralisable faecal toxin, then the diagnosis is often missed by sigmoidoscopy and rectal biopsy.
对241例接受胃肠道手术的患者进行了前瞻性研究。58例患者（24%）出现术后腹泻，在使用抗生素后更为常见。9例患者（4%）粪便中具有可中和的假膜性结肠炎特征性毒素，且抗体滴度较高。从所有粪便中可检测到可中和毒素的患者粪便中分离出了产毒素艰难梭菌菌株。如果将假膜性结肠炎定义为存在可中和的粪便毒素，那么乙状结肠镜检查和直肠活检常常会漏诊。
