Keighley M R, Youngs D, Johnson M, Allan R N, Burdon D W
Gut. 1982 May;23(5):410-4. doi: 10.1136/gut.23.5.410.
The incidence of Clostridium difficile cytotoxin has been studied in 69 consecutive patients with inflammatory bowel disease complicated by severe diarrhoea or ileostomy flux during 74 admissions to hospital. The cytotoxin was identified in only four patients, all of whom had received antimicrobials. Clostridium difficle, but not cytotoxin, was identified in 10 of 43 admissions. This followed antimicrobial prophylaxis to cover a recent operation in two patients, and five were on long-term sulphasalazine. Only three patients with Clostridium difficile had not received an antimicrobial within one month of the study. Isolation of Clostridium difficile alone is of doubtful pathological significance, as it spontaneously disappeared without treatment in all patients.
对74次住院期间连续69例患有炎性肠病并伴有严重腹泻或回肠造口引流的患者进行了艰难梭菌细胞毒素发生率的研究。仅在4例患者中发现了细胞毒素，所有这些患者均接受过抗菌药物治疗。在43次住院中有10次检测出艰难梭菌，但未检测到细胞毒素。其中2例患者因近期手术接受了抗菌药物预防治疗，5例患者长期服用柳氮磺胺吡啶。在研究的一个月内，只有3例艰难梭菌患者未接受过抗菌药物治疗。仅分离出艰难梭菌的病理意义存疑，因为所有患者未经治疗该菌就自行消失了。
