Hill S Y
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213.
Alcohol Clin Exp Res. 1993 Aug;17(4):733-9. doi: 10.1111/j.1530-0277.1993.tb00831.x.
Sisters of alcoholics from high-density multigenerational families were assessed to determine personality characteristics. Spousal similarity was evaluated in proband/spouse pairs and in spouse pairs from the parental generation, allowing for comparisons of selection versus contagion as explanations for this similarity. Sisters were found to differ from control women with respect to Alienation and Social Closeness from the Multidimensional Personality Questionnaire, and Scale 6 (Paranoia) from the Minnesota Multiphasic Personality Inventory. Only spouses from the parental generation were similar on Alienation, suggesting that exposure over time (contagion) leads to greater similarity in parents from High-Risk families. Modest correlations in spouse pairs from both generations suggest that assortative mating for Social Closeness occurs among the parents of these individuals from High-Risk families, and further suggest that a diminished level of Social Closeness for sisters of alcoholics may be mediated in part by additive genetic variance. It is concluded that assortative mating for particular traits may contribute to increased risk for alcoholism. Also, failure to mate assortatively for other traits (e.g., Traditionalism, Harm Avoidance) may also contribute to increased rates in High-Risk families.
对来自高密度多代家庭的酗酒者姐妹进行评估,以确定其性格特征。在先证者/配偶对以及父母代的配偶对中评估配偶相似性,以便比较选择与感染,作为这种相似性的解释。发现这些姐妹在多维人格问卷中的疏离感和社会亲密度以及明尼苏达多相人格量表的第6分量表(偏执狂)方面与对照女性存在差异。只有父母代的配偶在疏离感上相似,这表明随着时间的推移(感染)会导致高危家庭父母之间有更大的相似性。两代配偶对之间的适度相关性表明,这些高危家庭个体的父母之间存在社会亲密度的选型交配,进一步表明,酗酒者姐妹社会亲密度水平的降低可能部分由加性遗传方差介导。得出的结论是,特定性状的选型交配可能会增加酗酒风险。此外,在其他性状(如传统主义、避免伤害)上未能进行选型交配也可能导致高危家庭发病率上升。