Worobec T G, Turner W M, O'Farrell T J, Cutter H S, Bayog R D, Tsuang M T
Harvard Medical School, Boston, Massachusetts.
Alcohol Clin Exp Res. 1990 Dec;14(6):887-92. doi: 10.1111/j.1530-0277.1990.tb01832.x.
The association between parental history of alcoholism and the nature of alcoholism was assessed using a more reliable measure of family history (Family Tree Questionnaire) and a more comprehensive inventory of alcoholism (Alcohol Use Inventory) than used in earlier studies. Parental alcoholism was associated with more severe alcoholism on most parameters of alcohol use (age of onset, quantity, frequency, preoccupation, and sustained use) and alcohol-related problems (social, vocational, physical, cognitive, and loss of control). The association between parental history of alcoholism and more severe alcoholism in the probands was independent of age of onset of alcoholism, current age, socioeconomic background, and marital status. Parental history positive (PH+) alcoholics were more reliant on alcohol to manage their moods but did not differ significantly from parental history negative (PH-) alcoholics in the use of alcohol to improve sociability or mental functioning or to cope with marital problems. Surprisingly, the degree of concern, guilt, and worry over the negative consequences of drinking was not significantly different for PH+ alcoholics although the negative consequences were clearly much more severe for this group. While the data are inconclusive about the reasons for more severe alcoholism in PH+ alcoholics, greater reliance on ethanol to manage moods and a relative insensitivity to negative consequences could theoretically account for the vulnerability to more severe alcoholism found in PH+ alcoholics.
与早期研究相比,本研究使用了更可靠的家族史测量方法(家谱问卷)和更全面的酗酒情况清单(酒精使用清单),来评估父母酗酒史与酗酒性质之间的关联。在大多数饮酒参数(发病年龄、饮酒量、饮酒频率、对酒的专注程度和持续饮酒情况)以及与酒精相关的问题(社交、职业、身体、认知和失控)方面,父母酗酒与更严重的酗酒情况相关。先证者的父母酗酒史与更严重的酗酒之间的关联,独立于酗酒的发病年龄、当前年龄、社会经济背景和婚姻状况。父母有酗酒史呈阳性(PH+)的酗酒者在调节情绪时更依赖酒精,但在通过饮酒来提高社交能力、改善心理功能或应对婚姻问题方面,与父母无酗酒史呈阴性(PH-)的酗酒者没有显著差异。令人惊讶的是,尽管饮酒的负面后果对PH+酗酒者显然要严重得多,但他们对饮酒负面后果的担忧、内疚和忧虑程度与PH-酗酒者并无显著差异。虽然关于PH+酗酒者酗酒情况更严重的原因的数据尚无定论,但理论上,更多地依赖乙醇来调节情绪以及对负面后果相对不敏感,可能是导致PH+酗酒者更容易出现更严重酗酒情况的原因。