Lockwood G G, Chakrabarti M K, Whitwam J G
Department of Anaesthesia, Hammersmith Hospital, London.
Anaesthesia. 1993 Sep;48(9):748-52. doi: 10.1111/j.1365-2044.1993.tb07582.x.
The uptake of isoflurane at a constant end-expired concentration of 1.5% in oxygen was studied in 15 women, ASA 1 or 2, undergoing elective total abdominal hysterectomy. The anaesthetic was administered by a simple computer-controlled to-and-fro closed system. After an initial period of wash-in to the system, the rate of uptake of isoflurane decreased bi-exponentially with a rapid reduction during the first 15 min. Perturbations from this bi-exponential decline reflect changes in cardiac output. The mean (SD) cumulative use of isoflurane was 4.5 (0.43) ml after 30 min and 7.3 (0.79) ml after 60 min.
在15名美国麻醉医师协会（ASA）分级为1或2级、接受择期全腹子宫切除术的女性患者中，研究了在氧气中终末呼气浓度恒定为1.5%时异氟烷的摄取情况。麻醉通过简单的计算机控制往返式封闭系统给药。在系统初始的吸入期后，异氟烷的摄取速率呈双指数下降，在最初15分钟内迅速降低。这种双指数下降的扰动反映了心输出量的变化。30分钟后异氟烷的平均（标准差）累积使用量为4.5（0.43）毫升，60分钟后为7.3（0.79）毫升。
