Higuchi H, Satoh T, Arimura S, Kanno M, Endoh R
Department of Anesthesiology, National Defense Medical College, Saitama, Japan.
Anesth Analg. 1993 Nov;77(5):1018-21. doi: 10.1213/00000539-199311000-00025.
Serum inorganic fluoride levels in obese versus control patients were compared during and after sevoflurane anesthesia. Mean serum inorganic fluoride levels in the obese group increased more rapidly and were significantly higher than in the control group at each sampling time (P < 0.01). The area under the curve of fluoride concentration, versus time up to 24 h and 48 h in the obese patients, was significantly greater than that in the nonobese patients (P < 0.001). Peak serum fluoride level in the obese patients was 51.7 +/- 2.5 mumol/L and exceeded 50 mumol/L for nearly 2 h. Our study showed that serum fluoride concentrations between mildly obese and nonobese patients differed during and after sevoflurane anesthesia.
在七氟醚麻醉期间及之后，对肥胖患者与对照患者的血清无机氟水平进行了比较。肥胖组的平均血清无机氟水平上升更快，且在每个采样时间均显著高于对照组（P < 0.01）。肥胖患者在24小时和48小时内氟化物浓度与时间曲线下的面积显著大于非肥胖患者（P < 0.001）。肥胖患者的血清氟峰值水平为51.7 +/- 2.5 μmol/L，且超过50 μmol/L近2小时。我们的研究表明，在七氟醚麻醉期间及之后，轻度肥胖患者与非肥胖患者的血清氟浓度存在差异。
