豚鼠肝微粒体制剂中磷脂的消耗与恢复对尿苷二磷酸葡萄糖醛酸基转移酶活性的影响。
Effect on uridine diphosphate glucuronyltransferase activity of depleting and restoring phospholipids to guinea-pig liver microsomal preparations.
作者信息
Berry C S, Caldecourt M, Hallinan T
出版信息
Biochem J. 1976 Mar 15;154(3):783-5. doi: 10.1042/bj1540783.
Abstract
Phospholipid depletion substantially inhibited the maximum demonstrable activities of the forward (glucuronidation) and reverse reactions of UDP-glucuronyltransferase towards p-nitrophenol in guinea-pig liver microsomal preparations. Dispersions of liver phospholipids restored activity, whereas non-phospholipid amphipaths failed to do so effectively. These results suggest that the system is probably phospholipid-dependent rather than conformationally constrained by phospholipids.
摘要
磷脂耗竭在很大程度上抑制了豚鼠肝微粒体制剂中UDP-葡糖醛酸基转移酶对对硝基苯酚的正向（葡糖醛酸化）和逆向反应的最大可显示活性。肝磷脂分散体可恢复活性，而非磷脂两性离子则不能有效恢复活性。这些结果表明，该系统可能依赖于磷脂，而非受磷脂的构象限制。
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本文引用的文献
1
The phospholipid-dependence of UDP-glucuronyltransferase.尿苷二磷酸葡萄糖醛酸基转移酶对磷脂的依赖性
Biochem Biophys Res Commun. 1969 Nov 6;37(4):567-75. doi: 10.1016/0006-291x(69)90846-8.
2
Activation of microsomal UDP glucuronyltransferase by phospholipases.磷脂酶对微粒体UDP葡萄糖醛酸基转移酶的激活作用。
Chem Biol Interact. 1971 Aug;3(4):282-4. doi: 10.1016/0009-2797(71)90061-5.
3
The phospholipid-dependence of uridine diphosphate glucuronyltransferase. Reactivation of phospholipase A-inactivated enzyme by phospholipids and detergents.尿苷二磷酸葡糖醛酸基转移酶的磷脂依赖性。磷脂酶A失活的酶被磷脂和去污剂重新激活。
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J Steroid Biochem. 1972 Jan;3(1):1-10. doi: 10.1016/0022-4731(72)90005-2.
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Kinetic properties of different forms of hepatic UDPglucuronyltransferase.不同形式的肝脏UDP葡萄糖醛酸转移酶的动力学特性。
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8
Regulation of microsomal enzymes by phospholipids. II. Acitvation of hepatic uridine diphosphate-glucuronyltransferase.磷脂对微粒体酶的调节作用。II. 肝尿苷二磷酸葡糖醛酸基转移酶的激活
J Biol Chem. 1971 Aug 10;246(15):4649-56.
9
Spontaneous and detergent activation of a glucuronyltransferase in vitro.体外葡糖醛酸基转移酶的自发激活和去污剂激活
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10
Influence of membrane lipids on the regulatory properties of UDP-glucuronyltransferase.膜脂对UDP-葡萄糖醛酸基转移酶调节特性的影响。
Eur J Biochem. 1973 Sep 21;38(1):59-63. doi: 10.1111/j.1432-1033.1973.tb03033.x.
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