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1
Effect on uridine diphosphate glucuronyltransferase activity of depleting and restoring phospholipids to guinea-pig liver microsomal preparations.豚鼠肝微粒体制剂中磷脂的消耗与恢复对尿苷二磷酸葡萄糖醛酸基转移酶活性的影响。
Biochem J. 1976 Mar 15;154(3):783-5. doi: 10.1042/bj1540783.
2
Guinea pig liver microsomal UDP-glucuronyltransferase: compartmented or phospholipid-constrained?豚鼠肝微粒体UDP-葡萄糖醛酸基转移酶：是区室化的还是受磷脂限制的？
Biochim Biophys Acta. 1975 Oct 22;403(2):335-44. doi: 10.1016/0005-2744(75)90063-7.
3
The phospholipid-dependence of uridine diphosphate glucuronyltransferase. Effect of protein deficiency on the phospholipid composition and enzyme activity of rat liver microsomal fraction.尿苷二磷酸葡萄糖醛酸基转移酶的磷脂依赖性。蛋白质缺乏对大鼠肝脏微粒体部分磷脂组成和酶活性的影响。
Biochem J. 1974 Mar;137(3):567-74. doi: 10.1042/bj1370567.
4
The phospholipid-dependence of uridine diphosphate glucuronyltransferase. Phospholipid depletion and re-activation of guinea-pig liver microsomal enzyme.尿苷二磷酸葡糖醛酸基转移酶的磷脂依赖性。豚鼠肝微粒体酶的磷脂耗竭与再激活。
Biochem J. 1977 Apr 1;163(1):117-24. doi: 10.1042/bj1630117.
5
The phospholipid-dependence of uridine diphosphate glucuronyltransferase. Temperature-dependence of microsomal enzyme activity and thermotropic changes in membrane structure.尿苷二磷酸葡萄糖醛酸基转移酶的磷脂依赖性。微粒体酶活性的温度依赖性及膜结构的热致变化。
Biochem J. 1978 Oct 1;175(1):115-24. doi: 10.1042/bj1750115.
6
The phospholipid-dependence of uridine diphosphate glucuronyltransferase. Reactivation of phospholipase A-inactivated enzyme by phospholipids and detergents.尿苷二磷酸葡糖醛酸基转移酶的磷脂依赖性。磷脂酶A失活的酶被磷脂和去污剂重新激活。
Biochem J. 1971 Aug;123(5):875-82. doi: 10.1042/bj1230875.
7
Phospholipid-dependence of oestrone UDP-glucuronyltransferase and p-nitrophenol UDP-glucuronyltransferase.雌酮UDP-葡萄糖醛酸基转移酶和对硝基苯酚UDP-葡萄糖醛酸基转移酶的磷脂依赖性
Biochem J. 1979 Apr 1;179(1):59-65. doi: 10.1042/bj1790059.
8
Phospholipid dependence of UDP-glucuronyltransferase.
Biochim Biophys Acta. 1978 Feb 21;507(2):198-206. doi: 10.1016/0005-2736(78)90416-9.
9
The phospholipid-dependence of uridine diphosphate glucuronyltransferase. Temperature-dependence of microsomal enzyme activity (reverse reaction).尿苷二磷酸葡萄糖醛酸基转移酶的磷脂依赖性。微粒体酶活性的温度依赖性（逆反应）。
Biochem J. 1980 Feb 1;185(2):521-6. doi: 10.1042/bj1850521.
10
Differentiation of homologous forms of hepatic microsomal UDP-glucuronyltransferase. I. Evidence for the glucuronidation of o-aminophenol and p-nitrophenol by separate enzymes.肝微粒体UDP-葡萄糖醛酸基转移酶同源形式的分化。I. 邻氨基苯酚和对硝基苯酚由不同酶进行葡萄糖醛酸化的证据。
Biochim Biophys Acta. 1973 May 5;309(1):67-74. doi: 10.1016/0005-2744(73)90318-5.

引用本文的文献

1
The phospholipid-dependence of uridine diphosphate glucuronyltransferase. Temperature-dependence of microsomal enzyme activity (reverse reaction).尿苷二磷酸葡萄糖醛酸基转移酶的磷脂依赖性。微粒体酶活性的温度依赖性（逆反应）。
Biochem J. 1980 Feb 1;185(2):521-6. doi: 10.1042/bj1850521.
2
The phospholipid-dependence of uridine diphosphate glucuronyltransferase. Phospholipid depletion and re-activation of guinea-pig liver microsomal enzyme.尿苷二磷酸葡糖醛酸基转移酶的磷脂依赖性。豚鼠肝微粒体酶的磷脂耗竭与再激活。
Biochem J. 1977 Apr 1;163(1):117-24. doi: 10.1042/bj1630117.
3
Phospholipid-dependence of oestrone UDP-glucuronyltransferase and p-nitrophenol UDP-glucuronyltransferase.雌酮UDP-葡萄糖醛酸基转移酶和对硝基苯酚UDP-葡萄糖醛酸基转移酶的磷脂依赖性
Biochem J. 1979 Apr 1;179(1):59-65. doi: 10.1042/bj1790059.
4
The phospholipid-dependence of uridine diphosphate glucuronyltransferase. Temperature-dependence of microsomal enzyme activity and thermotropic changes in membrane structure.尿苷二磷酸葡萄糖醛酸基转移酶的磷脂依赖性。微粒体酶活性的温度依赖性及膜结构的热致变化。
Biochem J. 1978 Oct 1;175(1):115-24. doi: 10.1042/bj1750115.
5
Phospholipid content and activity of pure uridine diphosphate-glucuronyltransferase from rat liver.大鼠肝脏中纯尿苷二磷酸葡萄糖醛酸转移酶的磷脂含量与活性
Biochem J. 1978 Jun 1;171(3):821-4. doi: 10.1042/bj1710821.
6
Separation of oestrone UDP-glucuronyltransferase and p-nitrophenol UDP-glucuronyltransferase activities.雌酮UDP-葡萄糖醛酸基转移酶和对硝基苯酚UDP-葡萄糖醛酸基转移酶活性的分离。
Biochem J. 1978 Jun 1;171(3):659-63. doi: 10.1042/bj1710659.

本文引用的文献

1
The phospholipid-dependence of UDP-glucuronyltransferase.尿苷二磷酸葡萄糖醛酸基转移酶对磷脂的依赖性
Biochem Biophys Res Commun. 1969 Nov 6;37(4):567-75. doi: 10.1016/0006-291x(69)90846-8.
2
Activation of microsomal UDP glucuronyltransferase by phospholipases.磷脂酶对微粒体UDP葡萄糖醛酸基转移酶的激活作用。
Chem Biol Interact. 1971 Aug;3(4):282-4. doi: 10.1016/0009-2797(71)90061-5.
3
The phospholipid-dependence of uridine diphosphate glucuronyltransferase. Reactivation of phospholipase A-inactivated enzyme by phospholipids and detergents.尿苷二磷酸葡糖醛酸基转移酶的磷脂依赖性。磷脂酶A失活的酶被磷脂和去污剂重新激活。
Biochem J. 1971 Aug;123(5):875-82. doi: 10.1042/bj1230875.
4
Studies on a solubilized oestriol 16 -glucuronyltransferase from human liver microsomes.人肝微粒体中一种可溶性雌三醇16 -葡糖醛酸基转移酶的研究。
J Steroid Biochem. 1972 Jan;3(1):1-10. doi: 10.1016/0022-4731(72)90005-2.
5
Kinetic properties of different forms of hepatic UDPglucuronyltransferase.不同形式的肝脏UDP葡萄糖醛酸转移酶的动力学特性。
Biochim Biophys Acta. 1972 Oct 12;284(2):394-405. doi: 10.1016/0005-2744(72)90135-0.
6
Studies on microsomal nucleoside diphosphatase of rat hepatocytes. Its purification, intramembranous localization, and turnover.大鼠肝细胞微粒体核苷二磷酸酶的研究。其纯化、膜内定位及周转
J Biol Chem. 1972 May 25;247(10):2979-88.
7
Regulation of microsomal enzymes by phospholipids. IV. Species differences in the properties of microsomal UDP-glucuronyltransferase.磷脂对微粒体酶的调节作用。IV. 微粒体UDP-葡萄糖醛酸基转移酶性质的种属差异
Biochim Biophys Acta. 1972 Apr 7;268(1):61-9. doi: 10.1016/0005-2744(72)90197-0.
8
Regulation of microsomal enzymes by phospholipids. II. Acitvation of hepatic uridine diphosphate-glucuronyltransferase.磷脂对微粒体酶的调节作用。II. 肝尿苷二磷酸葡糖醛酸基转移酶的激活
J Biol Chem. 1971 Aug 10;246(15):4649-56.
9
Spontaneous and detergent activation of a glucuronyltransferase in vitro.体外葡糖醛酸基转移酶的自发激活和去污剂激活
Arch Biochem Biophys. 1967 Apr;120(1):198-203. doi: 10.1016/0003-9861(67)90614-5.
10
Influence of membrane lipids on the regulatory properties of UDP-glucuronyltransferase.膜脂对UDP-葡萄糖醛酸基转移酶调节特性的影响。
Eur J Biochem. 1973 Sep 21;38(1):59-63. doi: 10.1111/j.1432-1033.1973.tb03033.x.

豚鼠肝微粒体制剂中磷脂的消耗与恢复对尿苷二磷酸葡萄糖醛酸基转移酶活性的影响。

Effect on uridine diphosphate glucuronyltransferase activity of depleting and restoring phospholipids to guinea-pig liver microsomal preparations.

作者信息

Berry C S, Caldecourt M, Hallinan T

出版信息

Biochem J. 1976 Mar 15;154(3):783-5. doi: 10.1042/bj1540783.

DOI:10.1042/bj1540783
PMID:821474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1172782/
Abstract

Phospholipid depletion substantially inhibited the maximum demonstrable activities of the forward (glucuronidation) and reverse reactions of UDP-glucuronyltransferase towards p-nitrophenol in guinea-pig liver microsomal preparations. Dispersions of liver phospholipids restored activity, whereas non-phospholipid amphipaths failed to do so effectively. These results suggest that the system is probably phospholipid-dependent rather than conformationally constrained by phospholipids.

摘要

磷脂耗竭在很大程度上抑制了豚鼠肝微粒体制剂中UDP-葡糖醛酸基转移酶对对硝基苯酚的正向（葡糖醛酸化）和逆向反应的最大可显示活性。肝磷脂分散体可恢复活性，而非磷脂两性离子则不能有效恢复活性。这些结果表明，该系统可能依赖于磷脂，而非受磷脂的构象限制。