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雌酮UDP-葡萄糖醛酸基转移酶和对硝基苯酚UDP-葡萄糖醛酸基转移酶活性的分离。

Separation of oestrone UDP-glucuronyltransferase and p-nitrophenol UDP-glucuronyltransferase activities.

作者信息

Tukey R H, Billings R E, Tephly T R

出版信息

Biochem J. 1978 Jun 1;171(3):659-63. doi: 10.1042/bj1710659.

DOI:10.1042/bj1710659
PMID:96815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1184011/
Abstract

Rabbit liver UDP-glucuronyltransferase activity was resolved into two separate fractions on DEAE-cellulose, one containing most of the transferase activity toward oestrone and the other most of the activity toward p-nitrophenol. These two activities were completely separated by rechromatography of each fraction on a second DEAE-cellulose column.

摘要

兔肝UDP-葡萄糖醛酸基转移酶活性在DEAE-纤维素上被分离成两个独立的组分，一个组分含有大部分针对雌酮的转移酶活性，另一个组分含有大部分针对对硝基苯酚的活性。通过在第二个DEAE-纤维素柱上对每个组分进行再层析，这两种活性被完全分离。

相似文献

1
Separation of oestrone UDP-glucuronyltransferase and p-nitrophenol UDP-glucuronyltransferase activities.雌酮UDP-葡萄糖醛酸基转移酶和对硝基苯酚UDP-葡萄糖醛酸基转移酶活性的分离。
Biochem J. 1978 Jun 1;171(3):659-63. doi: 10.1042/bj1710659.
2
Phospholipid-dependence of oestrone UDP-glucuronyltransferase and p-nitrophenol UDP-glucuronyltransferase.雌酮UDP-葡萄糖醛酸基转移酶和对硝基苯酚UDP-葡萄糖醛酸基转移酶的磷脂依赖性
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本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
The solubilization and partial purification of a glucuronyl transferase from rabbit liver microsomes.兔肝微粒体中葡萄糖醛酸基转移酶的增溶与部分纯化
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3
Ethereal and N-linked glucuronide formation by normal and Gunn rats in vitro and in vivo.正常大鼠和冈恩大鼠在体内外形成醚类和N-连接葡糖醛酸苷的情况。
Biochem Biophys Res Commun. 1961 Nov 1;6:81-4. doi: 10.1016/0006-291x(61)90388-6.
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The synthesis of bilirubin glucuronide in animal and human liver.胆红素葡萄糖醛酸酯在动物和人类肝脏中的合成。
Biochem J. 1958 Dec;70(4):705-12. doi: 10.1042/bj0700705.
5
The enzymatic formation of bilirubin glucuronide.胆红素葡萄糖醛酸酯的酶促形成。
Arch Biochem Biophys. 1957 Jul;70(1):285-8. doi: 10.1016/0003-9861(57)90103-0.
6
Uridine diphosphate glucuronic acid as glucuronyl donor in the synthesis of ester, aliphatic and steroid glucuronides.尿苷二磷酸葡萄糖醛酸作为酯、脂肪族和类固醇葡萄糖醛酸苷合成中的葡萄糖醛酸基供体。
Biochem J. 1956 Dec;64(4):693-701. doi: 10.1042/bj0640693.
7
Partial purification of hepatic UDP-glucuronyltransferase. Studies of some of its properties.肝脏UDP-葡萄糖醛酸基转移酶的部分纯化及其某些性质的研究。
Biochim Biophys Acta. 1970 Jul 15;212(1):65-78. doi: 10.1016/0005-2744(70)90179-8.
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Effect of triton X-100 on the conjugation of tetrahydrocortisone, in vitro.曲拉通X-100对四氢可的松体外结合反应的影响。
Biochem Pharmacol. 1973 Sep 15;22(18):2319-27. doi: 10.1016/0006-2952(73)90013-0.
9
Mechanism of biosynthesis of thio- -D-glucuronides and thio- -D-glucosides.硫代-β-D-葡萄糖醛酸苷和硫代-β-D-葡萄糖苷的生物合成机制。
Biochem J. 1972 Sep;129(3):539-50. doi: 10.1042/bj1290539.
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Testosterone metabolism by gastrointestinal microsomes.胃肠道微粒体的睾酮代谢
Acta Physiol Scand. 1970 Aug;79(4):537-40. doi: 10.1111/j.1748-1716.1970.tb04755.x.